Simpson attended the University of Southern California (USC), where he played football for the USC Trojans and won the Heisman Trophy in 1968. He played professionally as a running back in the NFL for 11 seasons, primarily with the Buffalo Bills from 1969 to 1977. He also played for the San Francisco 49ers from 1978 to 1979. In 1973, he became the first NFL player to rush for more than 2,000 yards in a season. He holds the record for the single season yards-per-game average, which stands at 143.1. He was the only player to ever rush for over 2,000 yards in the 14-game regular season NFL format.
In 1994, Simpson was arrested and charged with the murders of his ex-wife, Nicole Brown Simpson, and her friend, Ron Goldman. He was acquitted by a jury after a lengthy and internationally publicized trial. The families of the victims subsequently filed a civil suit against him, and in 1997 a civil court awarded a $33.5 million judgment against him for the victims' wrongful deaths. In 2000, he moved to Florida to avoid paying any more of the liability judgment, settling in Miami.
In 2007, Simpson was arrested in Las Vegas, Nevada, and charged with the felonies of armed robbery and kidnapping. In 2008, he was convicted and sentenced to 33 years imprisonment, with a minimum of nine years without parole. He served his sentence at the Lovelock Correctional Center near Lovelock, Nevada. Simpson was granted parole on July 20, 2017. He was eligible for release from prison on October 1, 2017, and was released on that date.