images links abstract
Wiki Code Copy Tips Home

Huntington's disease

Huntington's disease (HD), also known as Huntington's chorea, is an inherited disorder that results in death of brain cells. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unsteady gait often follow. As the disease advances, uncoordinated, jerky body movements become more apparent. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. Mental abilities generally decline into dementia. The specific symptoms vary somewhat between people. Symptoms usually begin between 30 and 50 years of age, but can start at any age. The disease may develop earlier in life in each successive generation. About eight percent of cases start before the age of 20 years and typically present with symptoms more similar to Parkinson's disease. People with HD often underestimate the degree of their problems.

HD is typically inherited from a person's parents, although up to 10% of cases are due to a new mutation. The disease is caused by an autosomal dominant mutation in either of an individual's two copies of a gene called Huntingtin. This means a child of an affected person typically has a 50% chance of inheriting the disease. The Huntingtin gene provides the genetic information for a protein that is also called "huntingtin". Expansion of CAG (cytosine-adenine-guanine) triplet repeats in the gene coding for the Huntingtin protein results in an abnormal protein, which gradually damages cells in the brain, through mechanisms that are not fully understood. Diagnosis is by genetic testing, which can be carried out at any time, regardless of whether or not symptoms are present. This fact raises several ethical debates: the age at which an individual is considered mature enough to choose testing; whether parents have the right to have their children tested; and managing confidentiality and disclosure of test results.

There is no cure for HD. Full-time care is required in the later stages of the disease. Treatments can relieve some symptoms and in some improve quality of life. The best evidence for treatment of the movement problems is with tetrabenazine. HD affects about 4 to 15 in 100,000 people of European descent. It is rare among Japanese, while the occurrence rate in Africa is unknown. The disease affects men and women equally. Complications such as pneumonia, heart disease, and physical injury from falls reduce life expectancy. Suicide is the cause of death in about 9% of cases. Death typically occurs fifteen to twenty years from when the disease was first detected.

The first likely description of the disease was in 1841 by Charles Oscar Waters. The condition was described in further detail in 1872 by the physician George Huntington, after whom it is named. The genetic basis was discovered in 1993 by an international collaborative effort led by the Hereditary Disease Foundation. Research and support organizations began forming in the late 1960s to increase public awareness, to provide support for individuals and their families, and to promote research. Current research directions include determining the exact mechanism of the disease, improving animal models to aid with research, testing of medications to treat symptoms or slow the progression of the disease, and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease.



Source: Huntington's disease
List of The Walking Dead episodes
Seychelles
Money laundering
Atlanta Falcons
List of country calling codes
Al Baqa
Venice
List of 2017 albums
Logan Lucky
UEFA Champions League
China
Cara Delevingne
Methamphetamine
Battle of Dunkirk
Craigslist
Gigi Hadid
Albus Dumbledore
Thomas Jefferson
David Hasselhoff
David Fincher
Somalia
Bed size
Mick Jagger
World War I
Billions (TV series)
Nier: Automata
WrestleMania 33
Dick Van Dyke
Oakland Raiders
East India Company
Janis Joplin
Viola Davis
The Edge of Seventeen
Gold
Jeremy Clarkson
27 Club
Killing of Harambe
List of Grand Slam men's singles champions
13 Hours: The Secret Soldiers of Benghazi
Great Britain
Patton Oswalt
Tom Brady
Criminal Minds
Laurence Fishburne
Khaidi No. 150
Brexit
Anne Heche
Sigmund Freud
RSS
Kennedy family
Terry Crews
States and union territories of India
Kevin Kline
Carol Burnett
Cyprus
Kangana Ranaut
Guy Pearce
James Gandolfini
Lolita
Chandragupta Maurya
Los Angeles
Lucifer
Oxygen
Bubonic plague
Wallis Simpson
Melanie Griffith
Santa Clarita Diet
Charles II of England
Ileana D'Cruz
June Carter Cash
H. R. McMaster
Naga Chaitanya
Hoda Kotb
Joan Crawford
Rita Ora
Band of Brothers (miniseries)
Antoine Griezmann
Channing Tatum
Muslim
Poldark (2015 TV series)
Don Quixote
UFC 213
Camilla, Duchess of Cornwall
List of Marvel Cinematic Universe television series
Ian Somerhalder
Queen Latifah
List of Mr. Robot episodes
Tokyo Ghoul
Patrick Wilson (American actor)
Liev Schreiber
Star Trek: The Next Generation
Christian Pulisic
Elizabeth of York
Alice Cooper
Impeachment
Lithuania
Coyote
Tim McGraw
Uttar Pradesh
50 Cent
Paris Hilton
Russia
John Laurens
Mark Cuban
Sex in film
Salman Khan
Chris Jericho
Indian Railways
Animal
Rogue One
Gerald R. Ford-class aircraft carrier
Major depressive disorder
Brave New World
Kodak Black
Mercedes-Benz
The Shack
Tyrese Gibson
Don Johnson
Geena Davis
Space Shuttle Challenger disaster
2017 ATP World Tour
Quantum mechanics
Colin Firth
Piers Morgan
Grand Theft Auto V
Grant Gustin
Cthulhu
21 Savage
Chuck Schumer
Al-Bassah
Kenya
Miss World 2017
Andrew Lincoln
Neanderthal
Underworld: Blood Wars
Sterling K. Brown
List of The Flash episodes
Didier Drogba
How to Get Away with Murder (season 3)
Tom Jones (singer)
Stonehenge
Day of the Dead
Hirohito
Varun Dhawan
Dark web
Idina Menzel
Influenza
The Matrix
The Golden Girls
Ben Shapiro
Dawn of the Planet of the Apes
Tiananmen Square protests of 1989
Nelson Mandela
Richard Harris
Alexandra Daddario
Jhené Aiko
Hugh Hefner
Cabinet of Donald Trump
Kesha
James VI and I
Tupac Shakur
Monica Bellucci
Sadomasochism
The Texas Chain Saw Massacre
Donnie Yen
Circumcision
Blake Griffin
Tamannaah
Logan Paul
Larry Page
Saroo Brierley
Alexa Bliss
Grace Jones
Rachel Weisz
Artificial intelligence
List of Arrow episodes
Bangladesh
Gary Ridgway
Lyme disease
Fibonacci number
Roger Waters
Machine Gun Kelly (rapper)
Glee (TV series)
Crazy Ex-Girlfriend (TV series)
Amitabh Bachchan
Holly Hunter
Gunpowder Plot
2017 NFL season
John Hurt
Kwanzaa
Queen Elizabeth The Queen Mother
Antonio Banderas
Swami Vivekananda
The Legend of Zelda
Christopher Nolan
Ashley Olsen
Joel Edgerton
Sex position
Manchester City F.C.
Guyana
TIPS: To create new content for your website or blog...
  1. Enter the title of a Wikipedia article in the box above.
  2. Select your options using the checkboxes, or use default settings.
  3. Click the 'go' button to retrieve the article.
  4. Click the 'Copy Code' button to copy the source code of the article to your clipboard.
  5. Paste the source code into your favorite HTML editor.
  6. Edit the content to suit your needs.
  7. Publish your new content to your website or blog.
  8. IMPORTANT: Before publishing, be sure to make significant changes to avoid creating duplicate content.
buy this site
Custom Website Development