Tetrasomy X (also called XXXX syndrome, quadruple X, or 48,XXXX) is an extremely rare chromosomal disorder caused by the presence of four X chromosomes instead of two X chromosomes.
This condition occurs only in females, as there are no Y chromosomes present.
Tetrasomy X was first described in 1961, and since then approximately 100 cases have been reported worldwide. Approximately 60 affected females have been described in the medical literature.
Source: 48, XXXX
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